• Project Title: Combined Effects of PNC-27 and Acetone on the Growth of Breast Cancer Cells

  • BASIS Advisor: Dr. Zaslavsky

  • Internship Location: SUNY Downstate Medical Center

  • Onsite Mentor: Matthew Pincus

The process of ketosis relies on natural lipids as an energy source rather than standard carbohydrates. Because cancer thrives in the low pH environments most easily stimulated by a high sugar intake, the ketogenic diet acts as a blocker to the tumor growth process. Previous research has found that pnc-27 is an anti-cancer peptide that forces cancer cells into an apoptotic state by targeting a tumor suppressant site: HDM-2. Unfortunately, it does not prevent against recurrence or regrowth of said tumor. Paired together, pnc-27 and acetone, the smallest ketone produced by ketosis, can reasonably be expected to create long-term cancer growth. This project conducted at SUNY Downstate seeks to find the ideal of concentrations of both that must be paired together in order to optimize cancer death. Results from the experiment will be used to further cancer research in regards to cancer related peptides and dietary needs.